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Results : The results indicated that high drug loading, optimum size and desired zeta potential and transparency could be achieved with both SMEDDS and microemulsion.

The TEM studies indicated the absence of aggregation with both the systems.

The in vitro intestinal permeability results showed that the permeation of the drug from the microemulsion and SMEDDs was significantly higher than that obtained from the drug dispersion and marketed formulation.

Drugs administered orally are absorbed in the systemic circulation either via portal circulation or lymphatic transport.

SMEDDS is an isotropic mixture of oil, surfactant and co-surfactant, and drug substance; microemulsion can be generated rapidly upon gentle mixing with water or aqueous media.

Generally for oral preparation microemulsion preconcentrate (SMEDDS) is preferred over the regular microemulsion system because it will decrease the volume so it will become easy to fill in the soft gelatin capsule. Raloxifene is a second-generation SERM used to prevent osteoporosis in postmenopausal women.

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Correspondence Address: Hetal Thakkar Department of Pharmacy, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara India Source of Support: None, Conflict of Interest: None Background : Raloxifene, a second-generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women is administered orally in the form of a tablet.

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