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assisted with the crystallization in LCP and prepared the manuscript.

performed the thermal stability assay and assisted with the crystallization in LCP.

expressed the receptor, prepared the membrane, and performed the ligand-binding assay.

performed flexible ligand-receptor docking, and prepared the manuscript.

refined the structure and assisted with preparing the manuscript.

designed the receptor production strategy and assisted with preparing the manuscript.

The pocket is associated with an anion-binding region occupied by a phosphate ion.

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It shows that the drug resides in a much deeper pocket than in other aminergic GPCR structures.

I.), Grant-in-Aid for challenging Exploratory Research (T.

The work was also partly funded by the Biotechnology and Biological Sciences Research Council (BBSRC) BB/G023425/1 (S.

Tanaka, the technical coordinator of the ERATO Human Receptor Crystallography Project.

Johnson, a co-founder of the Diamond-MPL Project and R. purified and crystallized the receptor in LCP, optimized crystallization conditions, grew crystals for data collection, solved and refined the structure, and prepared the manuscript.

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